Reviva Pharma Announces Positive Data From DDI Study Of CYP3A4 Enzyme Effect On Brilaroxazine

RTTNews | 1048 hari yang lalu
Reviva Pharma Announces Positive Data From DDI Study Of CYP3A4 Enzyme Effect On Brilaroxazine

(RTTNews) - Biopharmaceutical company Reviva Pharmaceuticals Holdings, Inc. (RVPH) announced Thursday positive data from its recently completed clinical drug-drug interaction (DDI) study investigating the potential effect of CYP3A4 enzyme on brilaroxazine in healthy subjects.

The CYP3A4 enzyme plays a pivotal role in helping the body metabolize and remove small foreign molecules and is primarily found in the liver and intestine.

DDI evaluation is a critical clinical pharmacology study required by the U.S. Food and Drug Administration (FDA) and other regulatory agencies globally for approving a new drug to market.

Brilaroxazine is a serotonin/dopamine modulator in late-stage clinical development for the treatment of schizophrenia.

Following FDA guidelines, the DDI clinical study was designed to evaluate the drug interaction effect of a strong CYP3A4 inhibitor or inducer when co-administered with brilaroxazine in healthy volunteers.

Reviva believes that brilaroxazine's clinical safety is further reinforced with the positive results of this DDI study, which found no clinically significant interaction when combined with a CYP3A4 inhibitor.

Brilaroxazine is currently being evaluated in RECOVER, a pivotal global Phase 3, randomized, double-blind, placebo-controlled, multicenter study designed to assess the safety and efficacy of brilaroxazine in approximately 400 patients with acute schizophrenia compared to placebo. Topline data is expected in mid-2023.

For More Such Health News, visit rttnews.com

read more
European Economic News Preview: German GfK Consumer Confidence Due

European Economic News Preview: German GfK Consumer Confidence Due

Consumer sentiment from Germany and business confidence from Italy are the major economic reports due on Tuesday. At 3.00 am ET, the market research group GfK is slated to issue Germany's consumer sentiment survey results. The consumer confidence index is forecast to rise to -22.0 in November from -22.3 in October. Also, Statistics Sweden is set to issue monthly foreign trade data for September
RTTNews | 29 minit yang lalu
Europe Car Sales Grow For Third Month

Europe Car Sales Grow For Third Month

Europe's new car sales increased for the third straight month in September driven by the launch of new models, the European Automobile Manufacturers' Association, or ACEA, said Tuesday. New car sales advanced 10.0 percent year-on-year in September, following a 5.3 percent rise in August. This was the third consecutive increase in car sales.
RTTNews | 1j 9min yang lalu
European Shares Likely To Open On Tepid Note

European Shares Likely To Open On Tepid Note

European stocks are seen opening a tad lower on Tuesday as investors monitor the latest developments on U.S.-China trade front and look ahead to upcoming monetary policy announcements from several central banks, including the European Central Bank, the Federal Reserve and the Bank of Japan.
RTTNews | 1j 28min yang lalu
Sensex, Nifty Subdued In Lackluster Trade

Sensex, Nifty Subdued In Lackluster Trade

Indian shares were subdued on Tuesday as investors locked in some profits after recent gains, driven by optimism over easing global trade tensions and expectations of corporate earnings rebound.
RTTNews | 2j 18min yang lalu
Australian Market Extends Early Losses In Mid-market

Australian Market Extends Early Losses In Mid-market

The Australian stock market is extending its early losses in mid-market trading on Tuesday, reversing the gains in the previous session, despite the broadly positive cues from Wall Street overnight. The benchmark S&P/ASX 200 is falling well below the 9,050 level, with weakness across most sectors led by gold miners and technology stocks. Financial stocks are the only bright spot.
RTTNews | 3j 23min yang lalu
Asian Markets Mixed Amid Cautious Trades

Asian Markets Mixed Amid Cautious Trades

Asian stock markets are mixed on Tuesday, following the positive cues from Wall Street overnight, as traders remain cautious and are reluctant to take major positions ahead of the monetary policy announcements from the European Central Bank, the US Fed and the Bank of Japan this week. Optimism about a potential U.S.-China trade deal and an interest rate cut by the Fed are aiding market sentiment.
RTTNews | 3j 54min yang lalu
Sensex, Nifty To See Muted Start

Sensex, Nifty To See Muted Start

Indian shares look set to open on a muted note Tuesday, tracking mostly weak cues from other Asian markets.
RTTNews | 4j 16min yang lalu
Japanese Market Modestly Lower

Japanese Market Modestly Lower

The Japanese stock market is trading modestly lower on Tuesday, reversing some of the strong gains in the previous session, despite the broadly positive cues from Wall Street overnight. The Nikkei 225 is falling below the 50,400 level, with a mixed performance across most sectors.
RTTNews | 5j 23min yang lalu