Orchard Therapeutics Gets Swissmedic Approval For Libmeldy In Early-onset MLD

RTTNews | il y a 625
Orchard Therapeutics Gets Swissmedic Approval For Libmeldy In Early-onset MLD

(RTTNews) - Gene therapy leader Orchard Therapeutics plc (ORTX) announced Monday the Swiss Agency for Therapeutic Products (Swissmedic) has approved Libmeldy (atidarsagene autotemcel), a hematopoietic stem cell (HSC) gene therapy, for the treatment of early-onset metachromatic leukodystrophy (MLD).

MLD is a rare, fatal genetic disorder caused by a mutation in the gene responsible for encoding the enzyme arylsulfatase A (ARSA) leading to neurological damage and developmental regression.

Libmeldy aims to correct the underlying genetic cause of MLD by inserting a working copy of the ARSA gene into the genome of a patients' own HSCs. The genetically modified cells are infused back into the patient, where they can naturally migrate across the blood-brain barrier into the central nervous system, engraft, and express the functional enzyme.

In clinical trials, treatment with Libmeldy resulted in the preservation of cognitive development and maintenance of motor function past ages at which untreated patients showed severe cognitive and motor impairments.

read more
Thai Bourse May Halt Losing Streak On Thursday

Thai Bourse May Halt Losing Streak On Thursday

The Thai stock market has moved lower in back-to-back sessions, slipping almost 15 points or 1.2 percent along the way. The Stock Exchange of Thailand now sits just beneath the 1,250-point plateau although it may stop the bleeding on Thursday.
RTTNews | il y a 5 minutes
Australian Market Slightly Lower

Australian Market Slightly Lower

The Australian market is slightly lower in choppy trading on Thursday, giving up some of the gains in the previous session, despite the broadly positive cues from Wall Street overnight. The benchmark S&P/ASX 200 is falling below the 8,950 level, with weakness in iron ore miners, energy and technology stocks partially offset by gains in financial stocks.
RTTNews | il y a 13 minutes
Indonesia Shares Tipped To Open In The Green

Indonesia Shares Tipped To Open In The Green

The Indonesia stock market has moved higher in two of three trading days since the end of the two-day slide in which it had fallen almost 85 points or 1.1 percent. The Jakarta Composite Index now sits just above the 7,935-point plateau and it may add to its winnings on Thursday.
RTTNews | il y a 35 minutes
Hong Kong Shares Poised To End Two-Day Slide

Hong Kong Shares Poised To End Two-Day Slide

The Hong Kong stock market has finished lower in consecutive trading days, tumbling almost 630 points or 2.5 percent along the way. The Hang Seng Index now rests just above the 25,200-point plateau although it may find traction on Thursday.
RTTNews | il y a 50 minutes
China Stock Market May Stop The Bleeding On Thursday

China Stock Market May Stop The Bleeding On Thursday

The China stock market has finished lower in two straight sessions, retreating more than 80 points or 2.1 percent along the way. The Shanghai Composite Index now sits just above the 3,800-point plateau although it's due for support on Thursday.
RTTNews | il y a 1h 5min
Taiwan Stock Market May Extend Winning Streak

Taiwan Stock Market May Extend Winning Streak

The Taiwan stock market has tracked higher in three straight sessions, gathering more than 750 points or 3.1 percent along the way. The Taiwan Stock Exchange now rests just beneath the 24,520-point plateau and it may add to its winnings again on Thursday.
RTTNews | il y a 1h 35min
Singapore Stock Market May Extend Wednesday's Gains

Singapore Stock Market May Extend Wednesday's Gains

The Singapore stock market bounced higher again on Wednesday, one day after snapping the five-day winning streak in which it had climbed almost 70 points or 1.6 percent. The Straits Times Index now sits just above the 4,245-point plateau and it may pick up steam on Thursday.
RTTNews | il y a 2h 5min