Passage Bio Says New Interim Data From Imagine-1 Clinical Study Strengthens Safety Profile Of PBGM01

RTTNews | il y a 890
Passage Bio Says New Interim Data From Imagine-1 Clinical Study Strengthens Safety Profile Of PBGM01

(RTTNews) - Genetic medicines company Passage Bio, Inc. (PASG) announced on Wednesday new interim safety, biomarker, and clinical development results from cohorts 1-3 in the Imagine-1 clinical study.

Imagine-1 is a Phase 1/2, global, open-label, dose-escalation study of the AAVhu68 gene therapy PBGM01 delivered by intra-cisterna magna (ICM) injection in four cohorts of pediatric subjects with early and late infantile GM1 Gangliosidosis (GM1).

GM1 is a rare, fatal lysosomal storage disease in which mutations in the GLB1 gene result in very low activity of the enzyme beta-galactosidase (ß-Gal).

The interim data include six treated patients from the first three cohorts. Cohort 1 (late infantile, low dose), Cohort 2 (late infantile, high dose) and Cohort 3 (early infantile, low dose) each consisted of two patients. Cohort 4 (early infantile, high dose) patients have been dosed and data is expected by mid-2023.

The company noted that new interim data from cohorts 1-3 continue to strengthen the favorable safety profile of PBGM01, with no treatment-related serious adverse events, no complications related to ICM administration and no evidence of DRG toxicity.

Passage has completed dosing of PBGM01 in the dose-escalation portion of the study and will evaluate dosing further patients at the current high dose and/or a higher dose as data from cohorts 1-4 mature.

For More Such Health News, visit rttnews.com

read more
U.S. Weekly Jobless Claims Unexpectedly Edge Down To 227,000

U.S. Weekly Jobless Claims Unexpectedly Edge Down To 227,000

A report released by the Labor Department on Thursday unexpectedly showed a slight decline by first-time claims for U.S. unemployment benefits in the week ended May 17th. The Labor Department said initial jobless claims edged down to 227,000, a decrease of 2,000 from the previous week's unrevised level of 229,000. The dip surprised economists, who had expected jobless claims to inch up to 230,000.
RTTNews | il y a 45 minutes
Euro Weakens After German Composite PMI Falls

Euro Weakens After German Composite PMI Falls

The euro weakened against other major currencies in the European session on Thursday, following the release of Germany's composite output index for May.
RTTNews | il y a 1h 57min
Bay Street Likely To Open On Weak Note

Bay Street Likely To Open On Weak Note

It's likely to be a weak start for stocks on Bay Street Thursday morning as investors may tread cautiously amid concerns about U.S. fiscal deficit, and continued uncertainty surrounding Trump administration's tariff moves. Weak crude oil and metal prices are likely to hurt as well.
RTTNews | il y a 2h 3min
FTSE 100 Notably Lower; Johnson Matthey Soars 32%

FTSE 100 Notably Lower; Johnson Matthey Soars 32%

U.K. stocks are down in negative territory on Thursday afternoon, in line with other major markets in Europe, as worries about U.S. fiscal deficit and rising bond yields weigh on equities. Investors, digesting the nation's economic data, are also awaiting more clarity on U.S. President Donald Trump's tariff plans.
RTTNews | il y a 2h 28min
Eurozone Private Sector Shrinks For First Time In 5 Months

Eurozone Private Sector Shrinks For First Time In 5 Months

The euro area private sector logged a renewed fall in May due to a sharp downturn in services activity, flash purchasing managers' survey compiled by S&P Global showed on Thursday. The flash composite output index fell to 49.5 in May from 50.4 in April. The score fell below the 50.0 no-change mark for the first time in five months.
RTTNews | il y a 2h 40min
Euro Falls Against Majors

Euro Falls Against Majors

The euro weakened against other major currencies in the Asian session on Thursday.
RTTNews | il y a 2h 47min
CAC 40 Down Nearly 1% On Growth Concerns

CAC 40 Down Nearly 1% On Growth Concerns

French stocks are drifting lower on Thursday amid rising concerns over a deteriorating U.S. fiscal outlook, a lack of clarity on tariff negotiations. Data showing a notable drop in France's manufacturing sentiment index is also weighing on stocks.
RTTNews | il y a 3h 7min