NeuroSense Says Phase 2b ALS Trial Meets Primary And Secondary Endpoints

RTTNews | 611日前
NeuroSense Says Phase 2b ALS Trial Meets Primary And Secondary Endpoints

(RTTNews) - NeuroSense Therapeutics Ltd. (NRSN) announced Tuesday that it met its primary safety and tolerability endpoints and achieved secondary clinical efficacy endpoints in the top-line results of its 6-month, randomized, placebo-controlled, double-blind segment the Company's Phase 2b amyotrophic lateral sclerosis (ALS) trial of PrimeC (PARADIGM).

The trial's secondary clinical efficacy outcome measure endpoints included Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) and Slow Vital Capacity (SVC), a measure of respiratory function.

NeuroSense expects to report an additional primary biomarker endpoint of the assessment of ALS hallmarks, TDP-43 and Prostagladin2, to evaluate PrimeC's biological activity, in the first half of 2024 following the completion of the analysis of participants' plasma.

The PARADIGM (NCT05357950) trial is a prospective, multinational, randomized, double-blind, placebo-controlled Phase 2b clinical trial of PrimeC in ALS.

NeuroSense expects to report results from a strategic collaboration with Biogen in January 2024, evaluating the impact of PrimeC on neurofilament levels in participants enrolled in PARADIGM.

Upon receipt of results, Biogen has the right of first refusal to co-develop/commercialize PrimeC for the treatment of ALS for a limited time following the results.

read more
Thai Stock Market May Spin Its Wheels On Friday

Thai Stock Market May Spin Its Wheels On Friday

The Thai stock market has moved higher in four straight sessions, gathering almost 50 points or 4.1 percent along the way. The Stock Exchange of Thailand now sits just above the 1,265-point plateau although it may be stuck in neutral on Friday.
RTTNews | 22分前
Continued Consolidation Called For Indonesia Stock Market

Continued Consolidation Called For Indonesia Stock Market

The Indonesia stock market has finished lower in back-to-back sessions, slipping more than 25 points or 0.3 percent in that span. The Jakarta Composite Index now sits just above the 7,490-point plateau and it may take further damage on Friday.
RTTNews | 52分前
Japanese Market Sharply Higher; Up 2%

Japanese Market Sharply Higher; Up 2%

Extending the gains in the previous three sessions, the Japanese market is sharply higher on Friday, following the mixed cues from Wall Street overnight. The Nikkei 225 is jumping almost 2 percent to above the 41,850 level, with gains across all sectors led by index heavyweights, exporters and technology stocks.
RTTNews | 56分前
Consolidation Likely For Hong Kong Shares

Consolidation Likely For Hong Kong Shares

The Hong Kong stock market has moved higher in four straight sessions, advancing more than 570 points or 2.4 percent along the way. The Hang Seng Index now rests just above the 25,080-point plateau although it may see some profit taking on Friday.
RTTNews | 1時7分前
Australian Market Notably Lower

Australian Market Notably Lower

The Australian stock market is trading notably lower on Friday, extending the slight losses in the previous session, following the mixed cues from Wall Street overnight. The benchmark S&P/ASX 200 is falling below the 8,800 level, with weakness in energy, financial and technology stocks partially offset by gains in mining stocks.
RTTNews | 1時17分前
Rally May Stall For China Stock Market

Rally May Stall For China Stock Market

The China stock market has tracked higher in four straight sessions, gathering almost 80 points or 2.4 percent along the way. The Shanghai Composite Index now sits just beneath the 3,640-point plateau although it may run out of steam on Friday.
RTTNews | 1時22分前
Taiwan Stock Market May Hand Back Thursday's Gains

Taiwan Stock Market May Hand Back Thursday's Gains

The Taiwan stock market has moved higher in two of three trading days since the end of the two-day losing streak in which it had slipped more than 270 points or 1.2 percent. The Taiwan Stock Exchange now sits just above the 24,000-point plateau although it's likely to turn lower again on Friday.
RTTNews | 1時52分前