Vanda Pharma Says Phase II Study Of VQW-765 To Treat Anxiety Showed Lower Stress Levels

RTTNews | 908 ngày trước
Vanda Pharma Says Phase II Study Of VQW-765 To Treat Anxiety Showed Lower Stress Levels

(RTTNews) - Vanda Pharmaceuticals Inc. (VNDA) reported on Friday results in a Phase II clinical study of VQW-765, a novel small molecule alpha 7 nicotinic acetylcholine receptor (a7-nAChR) partial agonist, in the treatment of acute performance anxiety in social situations, such as public speaking.

In clinical study VP-VQW-765-2201 (Study 2201), 230 volunteers with prior history of performance anxiety were randomized to receive a single dose of VQW-765 or placebo and were challenged with the standardized Trier Social Stress Test (TSST).

The TSST creates an acute stress by requiring participants to make an interview-style presentation in front of a panel who provides no feedback or encouragement. Participants who received VQW-765 showed numerically lower stress levels compared to those who received placebo.

In Study 2201, the stress level was assessed by the Subjective Units of Distress Scale (SUDS), a self-rating scale of level of nervousness or distress ranging from 0 to 100 at multiple timepoints during the duration of the TSST.

In particular, female participants (approximately 70% of the total participants) reported a larger magnitude and statistically significant response to VQW-765.

This is the first time that an alpha 7 nicotinic acetylcholine receptor (a7-nAChR) partial agonist has shown efficacy in a clinical study of performance anxiety.

Clinical data gathered indicates an adverse event profile similar to placebo and there were no observed negative cognitive effects reported by any participant in Study 2201.

If the results of the current study are confirmed, VQW-765 could be the first drug in the class of nicotinic receptor agonists approved to treat performance anxiety.

For More Such Health News, visit rttnews.com

read more
Kingfisher Q1 Sales Rise, Says Confident Of FY25 View; But Stock Down

Kingfisher Q1 Sales Rise, Says Confident Of FY25 View; But Stock Down

Home improvement retailer Kingfisher Plc reported Wednesday higher sales in its first quarter, benefited by improved results in UK & Ireland. Meanwhile, sales in France and Poland declined, and the company maintained its fiscal 2025 outlook. On the London Stock Exchange, Kingfisher shares were losing around 3.5 percent.
RTTNews | 2h 20phút trước
Bay Street Likely To Open On Mixed Note

Bay Street Likely To Open On Mixed Note

Canadian shares are likely to open on a mixed note Wednesday morning with investors tracking global cues and reacting to earnings from major Canadian banks. Investors are also awaiting earnings update from U.S.
RTTNews | 2h 32phút trước
FTSE 100 Down Marginally

FTSE 100 Down Marginally

UK stocks are marginally down in lackluster trade on Wednesday as investors look for directional clues after recent gains following U.S. President Donald Trump deciding to pause the recently announced 50% tariffs on imports from EU, paving the way for further trade negotiations.
RTTNews | 3h 21phút trước
German Unemployment Rises More Than Expected

German Unemployment Rises More Than Expected

Joblessness in Germany increased more than expected in May as a weak economy continued to impede job creation, official data revealed on Wednesday. The number of unemployed increased sharply by 34,000 in May compared to April's rise of 6,000, the Federal Employment Agency said. Economists expected a monthly increase of 12,000.
RTTNews | 3h 26phút trước
CAC 40 Down Marginally In Lackluster Trade

CAC 40 Down Marginally In Lackluster Trade

French stocks are moving in a tight range in cautious trade on Wednesday as investors digest a slew of domestic economic reports, and continue to assess the impact of Trump administration's trade policy on global economic growth.
RTTNews | 4h 35phút trước
DAX Modestly Lower In Cautious Trade

DAX Modestly Lower In Cautious Trade

German stocks are modestly lower on Wednesday with investors mostly making cautious moves, looking for directional clues after recent gains on the back of U.S. President Donald Trump's decision to pause tariffs on EU goods till July 9th.
RTTNews | 5h 2phút trước