INOVIO Reports Positive Interim Phase 1/2 Trial Results For INO-3107 For Respiratory Papillomatosis

RTTNews | 970天前
INOVIO Reports Positive Interim Phase 1/2 Trial Results For INO-3107 For  Respiratory Papillomatosis

(RTTNews) - Biotechnology company Inovio Pharmaceuticals Inc. (INO) announced Thursday positive interim results from an ongoing Phase 1/2 clinical trial evaluating INO-3107 for the treatment of HPV 6 and HPV 11-associated Recurrent Respiratory Papillomatosis (RRP) in adults.

In the first cohort of 21 participants, INO-3107 showed a statistically significant improvement in the clinical endpoint of the number of surgical interventions needed to control papilloma growth.

INO-3107 was also observed to be well-tolerated and immunogenic in the trial. INO-3107 received Orphan Drug Designation from the U.S. Food and Drug Administration (FDA) in July 2020.

INO-3107 was evaluated in a Phase 1/2 open-label, multicenter trial to assess its safety, tolerability, immunogenicity, and efficacy in 32 participants with HPV 6 and/or HPV 11-associated RRP.

Results from the second cohort of 11 patients are expected in the first half of 2023.

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Inovio Pharma Receives FDA Feedback On Submission Of BLA For INO-3107 To Treat RRP

Inovio Pharma Receives FDA Feedback On Submission Of BLA For INO-3107 To Treat RRP

Biotechnology company Inovio Pharmaceuticals, Inc. (INO) announced Tuesday that it has received feedback from the U.S. Food and Drug Administration (FDA) that data from its completed Phase 1/2 trial of INO-3107 for the treatment of RRP could support INOVIO's submission of a BLA for review under the FDA's accelerated approval program.
RTTNews | 608天前
Taiwan Bourse May Hand Back Monday's Gains

Taiwan Bourse May Hand Back Monday's Gains

The Taiwan stock market found renewed support on Monday, one session after ending the three-day winning streak in which it had jumped almost 680 points or 3.2 percent. The Taiwan Stock Exchange now sits just above the 21,790-point plateau although it may head south again on Tuesday. The global forecast for the Asian markets is murky ahead of key upcoming talks between the United States and China. The European markets were down and the U.S. bourses were flat and the Asian markets figure to split the difference. The TSE finished modestly higher on Monday following gains from the financial shares, technology stocks and plastics companies. For the day, the index gained 129.63 points or 0.60 percent to finish at 21,790.29 after trading between 21,717.52 and 21,866.27. Among the actives, Cathay Financial and CTBC Financial both collected 0.16 percent, while Mega Financial slid 0.25 percent, First Financial gained 0.55 percent, E Sun Financial improved 0.65 percent, Taiwan Semiconductor Manufacturing Company rallied 1.01 percent, United Microelectronics Corporation strengthened 1.44 percent, Hon Hai Precision climbed 0.98 percent, Largan Precision advanced 0.86 percent, Catcher Technology fell 0.24 percent, MediaTek increased 0.39 percent, Delta Electronics added 0.38 percent, Novatek Microelectronics dipped 0.20 percent, Nan Ya Plastics perked 0.17 percent, Asia Cement rose 0.24 percent and Formosa Plastics and Fubon Financial were unchanged.
RTTNews | 25分钟前
Singapore Shares May See Profit Taking On Tuesday

Singapore Shares May See Profit Taking On Tuesday

The Singapore stock market has climbed higher in five straight sessions, collecting more than 40 points or 1 percent along the way. The Straits Times Index now sits just above the 3,935-point plateau although it may be due for consolidation on Tuesday. The global forecast for the Asian markets is murky ahead of key upcoming talks between the United States and China. The European markets were down and the U.S. bourses were flat and the Asian markets figure to split the difference. The STI finished barely higher on Monday following gains from the retailers and mixed performances from the financial shares, property stocks and industrial issues. For the day, the index was up 2.03 points or 0.05 percent to finish at 3,936.32 after trading between 3,930.76 and 3,945.92. Among the actives, CapitaLand Ascendas REIT and CapitaLand Investment both declined 0.39 percent, while CapitaLand Integrated Commercial Trust lost 0.47 percent, City Developments stumbled 1.14 percent, Comfort DelGro improved 0.71 percent, DBS Group advanced 0.82 percent, DFI Retail surged 5.26 percent, Hongkong Land added 0.37 percent, Keppel DC REIT fell 0.45 percent, Keppel Ltd dropped 0.70 percent, Oversea-Chinese Banking Corporation collected 0.55 percent, SATS shed 0.64 percent, SembCorp Industries retreated 0.88 percent, Singapore Technologies Engineering tumbled 1.01 percent, SingTel slumped 0.77 percent, Yangzijiang Financial sank 0.68 percent, Yangzijiang Shipbuilding was down 0.44 percent and Mapletree Pan Asia Commercial Trust, Mapletree Industrial Trust, Mapletree Logistics Trust, Genting Singapore, Thai Beverage, Wilmar International, Seatrium Limited and Frasers Logistics & Commercial Trust were unchanged.
RTTNews | 55分钟前
Malaysia Shares Likely To Remain Rangebound

Malaysia Shares Likely To Remain Rangebound

The Malaysia stock market ticked higher again on Monday, one session after snapping the two-day winning streak in which it had gained almost 15 points or 1 percent. The Kuala Lumpur Composite Index now sits just beneath the 1,520-point plateau and it's expected to remain in that neighborhood again on Tuesday. The global forecast for the Asian markets is murky ahead of key upcoming talks between the United States and China. The European markets were down and the U.S. bourses were flat and the Asian markets figure to split the difference. The KLCI finished slightly higher on Monday following gains from the plantation stocks and mixed performances from the financials and telecoms. For the day, the index perked 2.62 points or 0.17 percent to finish at 1,519.41 after trading between 1,518.03 and 1,521.64. Among the actives, 99 Speed Mart Retail rose 0.48 percent, while Axiata increased 0.50 percent, Celcomdigi shed 0.52 percent, CIMB Group advanced 0.73 percent, Gamuda stumbled 1.47 percent, Hong Leong Financial eased 0.12 percent, IHH Healthcare added 0.58 percent, IOI Corporation perked 0.27 percent, Maxis slumped 0.83 percent, Maybank dipped 0.21 percent, MISC spiked 1.32 percent, Nestle Malaysia tumbled 1.79 percent, Petronas Chemicals soared 3.08 percent, Petronas Dagangan retreated 1.71 percent, Petronas Gas fell 0.22 percent, PPB Group rallied 1.10 percent, Press Metal climbed 0.81 percent, QL Resources surged 3.66 percent, RHB Bank collected 0.16 percent, Sime Darby sank 0.56 percent, SD Guthrie gathered 0.44 percent, Sunway improved 0.62 percent, Telekom Malaysia dropped 0.61 percent, Tenaga Nasional gained 0.56 percent, YTL Corporation declined 1.46 percent, YTL Power lost 0.28 percent and Kuala Lumpur Kepong, MRDIY and Public Bank were unchanged.
RTTNews | 1小时25分钟前
Japan Bourse May Spin Its Wheels On Tuesday

Japan Bourse May Spin Its Wheels On Tuesday

The Japan stock market has finished higher in two straight sessions, climbing more than 530 points or 1.7 percent along the way. The Nikkei 225 now sits just beneath the 38,090-point plateau although it may be stuck in neutral on Tuesday. The global forecast for the Asian markets is murky ahead of key upcoming talks between the United States and China. The European markets were down and the U.S. bourses were flat and the Asian markets figure to split the difference. The Nikkei finished modestly higher on Monday following gains from the financial shares and technology stocks, while the automobile producers were mixed. For the day, the index advanced 346.96 points or 0.92 percent to finish at 38,088.57 after trading between 38,018.22 and 38,178.01. Among the actives, Nissan Motor retreated 1.28 percent, while Mazda Motor advanced 0.96 percent, Toyota Motor shed 0.45 percent, Honda Motor eased 0.14 percent, Softbank Group soared 4.98 percent, Mitsubishi UFJ Financial and Sumitomo Mitsui Financial both climbed 1.02 percent, Mizuho Financial collected 2.13 percent, Mitsubishi Electric rallied 3.13 percent, Panasonic Holdings tumbled 1.95 percent, Hitachi accelerated 2.29 percent and Sony Group was unchanged. The lead from Wall Street is pedestrian as the major averages opened lower on Monday, moved into the green by midday but faded going into the close to end mixed and little changed.
RTTNews | 1小时40分钟前