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Aileron Terminates Phase 1b Breast Cancer Chemoprotection Trial Of ALRN-6924

RTTNews | 818 dagar sedan

Aileron Terminates Phase 1b Breast Cancer Chemoprotection Trial Of ALRN-6924

(RTTNews) - Aileron Therapeutics (ALRN) announced Tuesday that a review of initial data from its Phase 1b chemoprotection trial of ALRN-6924 in patients with p53-mutated breast cancer showed that patients in the trial experienced severe neutropenia (Grade 4) and alopecia.

The primary endpoint of the Phase 1b open-label trial, which was evaluating ALRN-6924 in patients with breast cancer receiving neoadjuvant or adjuvant treatment with docetaxel, doxorubicin, and cyclophosphamide, or "TAC" chemotherapy, was duration and incidence of severe neutropenia in cycle 1. Incidence of chemotherapy-induced alopecia (hair loss) was a secondary endpoint. Based on these findings, Aileron has decided to terminate the Phase 1b breast cancer trial and further development of ALRN-6924.

Aileron also announced that it is exploring a range of strategic alternatives to maximize shareholder value. The company has engaged Ladenburg Thalmann & Co., Inc. to act as a strategic advisor for this process.

Aileron said it does not intend to comment further on this process unless or until its Board of Directors has approved a definitive course of action or it is determined that other disclosure is appropriate.

Aileron has determined to reduce its remaining workforce from 9 to 3 full-time employees in the coming weeks. The company plans to retain the remaining employees to assist in executing the strategic alternatives review process.

Taggar: ALRN

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Ryanair FY25 Profit Down, But Stock Climbs On Revenue And Traffic Growth, Positive Outlook

Ryanair FY25 Profit Down, But Stock Climbs On Revenue And Traffic Growth, Positive Outlook

Shares of Ryanair Holdings Plc. were gaining around 6 percent in the early morning trading on the Nasdaq after the Irish low-cost airline reported Monday higher revenues and traffic in fiscal 2025, despite delivery delays from aerospace major Boeing Co. The company marked as the first airline in European Union to carry 200 million guests in one year. Meanwhile, Ryanair recorded weak annual profit.

RTTNews | 37 minuter sedan

U.S. Leading Economic Index Slumps More Than Expected In April

U.S. Leading Economic Index Slumps More Than Expected In April

The Conference Board released a report on Monday showing its reading on leading U.S. economic indicators slumped by more than expected in the month of April. The report said the leading economic index tumbled by 1.0 percent in April after sliding by a downwardly revised 0.8 percent in March.

RTTNews | 57 minuter sedan

Eurozone Growth Outlook Downgraded; Disinflation To Proceed More Swiftly: EU

Eurozone Growth Outlook Downgraded; Disinflation To Proceed More Swiftly: EU

Eurozone economic growth outlook was downgraded substantially for 2025 due to the impact of higher trade tariffs and elevated uncertainty and disinflation would proceed more swiftly than anticipated with headline inflation set to hit the 2 percent target by the middle of this year, the European Commission said Monday.

RTTNews | 2h 5minuter sedan

Dollar Index Extends Gains On Trade Deal Optimism

Dollar Index Extends Gains On Trade Deal Optimism

Rising optimism surrounding trade deals between the U.S. and its trading partners, and in particular the significant easing in trade tensions between the U.S. and China bolstered the U.S. dollar during the week ended May 16.

RTTNews | 3h 30minuter sedan

FTSE 100 Drifts Lower In Cautious Trade

FTSE 100 Drifts Lower In Cautious Trade

U.K. stocks are down in negative territory, losing ground after making a good upmove in the previous week. Investors, awaiting the outcome of a UK - European Union summit in London, are largely making cautious moves.

RTTNews | 4h 6minuter sedan

CAC 40 Moderately Lower; BNP Paribas Rises On Buyback Announcement

CAC 40 Moderately Lower; BNP Paribas Rises On Buyback Announcement

French stocks are down in negative territory on Monday, retreating from a one-month high recorded in the previous session, as investors make cautious moves amid some concerns about global growth following a downward revision in U.S. credit rating.

RTTNews | 4h 49minuter sedan

Sensex Drops 271 Points In Muted Session; Nifty Ends Below 24,950

Sensex Drops 271 Points In Muted Session; Nifty Ends Below 24,950

Indian shares fell modestly on Monday, with IT stocks leading losses after Moody's downgraded the U.S. credit rating by one notch to Aa1 from Aaa, citing rising levels of government debt and interest payments.

RTTNews | 4h 56minuter sedan

DAX Down Marginally In Cautious Trade

DAX Down Marginally In Cautious Trade

German stocks are exhibiting weakness on Monday in cautious trade after recent gains. Investors are assessing possible risks to global economic growth due to geopolitical tensions and tariff uncertainty, as well as a downgrade in U.S. sovereign debt.

RTTNews | 5h 15minuter sedan

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