Allakos Says Phase 3 Study Of Lirentelimab In EoD Missed Symptomatic Co-primary Goal

RTTNews | 985 dagar sedan
Allakos Says Phase 3 Study Of Lirentelimab In EoD Missed Symptomatic Co-primary Goal

(RTTNews) - Biotechnology company Allakos Inc. (ALLK) on Friday reported data from EoDyssey, a 24-week, Phase 3, randomized, double-blind, placebo-controlled study of lirentelimab in patients with biopsy confirmed eosinophilic duodenitis (EoD).

The trial met its histologic co-primary endpoint, but it did not achieve statistical significance on the patient reported symptomatic co-primary endpoint, in both the intent to treat (ITT) population and in a prespecified subpopulation.

The prespecified subpopulation was based on a post hoc analysis of the Company's phase 3 ENIGMA2 study and excluded certain patients with conditions that could confound the patient reported symptomatic endpoint. Although positive numerical trends in the symptomatic endpoint were observed in this prespecified subpopulation, the results were not statistically significant.

Currently Allakos is not planning to conduct additional studies in eosinophilic gastrointestinal diseases, but may do so in the future. Allakos is focusing development efforts for lirentelimab in atopic dermatitis and chronic spontaneous urticaria and on AK006.

read more
CAC 40 Moderately Lower In Cautious Trade

CAC 40 Moderately Lower In Cautious Trade

French stocks are under a bit of pressure on Wednesday amid uncertainty about Ukraine-Russia peace talks, and a lack of positive progress on the trade front. The recent downgrade of U.S. sovereign credit rating by Moody's weigh as well on investor sentiment.
RTTNews | 19 minuter sedan
Sensex, Nifty Snap Three-day Losing Streak

Sensex, Nifty Snap Three-day Losing Streak

Indian shares eked out modest gains on Wednesday, after having suffered heavy losses in the previous session amid rising geopolitical tensions, growing concerns over U.S. debt and a spike in Covid-19 cases in Southeast Asia.
RTTNews | 26 minuter sedan
DAX Drifts Lower On Geopolitical Concerns

DAX Drifts Lower On Geopolitical Concerns

German stocks are down in negative territory on Wednesday as investors make cautious moves, awaiting fresh news on the trade front. The impasse in Ukraine peace talks and data showing a bigger than expected increase in UK inflation weigh on sentiment.
RTTNews | 47 minuter sedan
Asian Shares Rise In Cautious Trade; Nikkei Drops On Yen Strength

Asian Shares Rise In Cautious Trade; Nikkei Drops On Yen Strength

Asian stocks ended mostly higher on Wednesday, with Japanese markets underperforming as the yen continued to strengthen on BoJ rate hike bets and data showed Japan's export growth continued to decelerate for the second consecutive month.
RTTNews | 2h 0minuter sedan
U.S. Dollar Falls Amid Risk-on Mood, Fed Rate Cut Bet

U.S. Dollar Falls Amid Risk-on Mood, Fed Rate Cut Bet

The U.S. dollar weakened against other major currencies in the Asian session on Wednesday amid increased risk-on mood, as some traders are still looking to cash in on the strong upside in the markets seen over the past several weeks. Furthermore, growing market acceptance that the Federal Reserve (Fed) will lower interest rates further this year amid evidence of diminishing inflationary pressure and a dismal growth forecast, also pushed the USD lower.
RTTNews | 3h 8minuter sedan
Japan Exports Growth Softens On Higher Trade Tariffs

Japan Exports Growth Softens On Higher Trade Tariffs

Japan's exports grew at a slower pace in April largely due to the higher tariffs imposed by the US administration, official data revealed Wednesday. Exports climbed 2.0 percent on a yearly basis in April, slower than the 4.0 percent increase in March, the Ministry of Finance reported. Exports have been rising since last September and the latest growth matched economists' expectations.
RTTNews | 4h 20minuter sedan
European Shares May Struggle At Open

European Shares May Struggle At Open

European stocks are seen opening little changed on Wednesday, with U.S. fiscal concerns, geopolitical tensions and the Fed outlook likely to be in focus.
RTTNews | 5h 14minuter sedan