EFFECTOR Says First Patient Dosed In Second Cohort Of Phase 1b Trial Of Zotatifin For COVID-19

RTTNews | 978 dagar sedan
EFFECTOR Says First Patient Dosed In Second Cohort Of Phase 1b Trial Of Zotatifin For COVID-19

(RTTNews) - Biopharmaceutical company eFFECTOR Therapeutics, Inc. (EFTR) announced Wednesday it has dosed the first patient in the second cohort of its Phase 1b clinical trial of zotatifin in non-hospitalized adults with confirmed COVID-19 infection.

The study is a double-blind, randomized, placebo-controlled trial evaluating the safety and antiviral activity of a single dose of zotatifin.

The dose escalation to the second cohort comes after the positive recommendation of the independent data safety monitoring board upon review of safety data from the first dose cohort.

The completed cohort also included the first subjects dosed with a sub-cutaneous formulation of zotatifin and preliminary analysis demonstrated equivalent plasma drug levels compared to IV delivery.

Zotatifin is a potent and sequence-selective small molecule inhibitor of eIF4A, a host protein required to unwind the complex secondary structures within the 5' untranslated region of the genome of SARS-CoV-2 and other RNA viruses.

Zotatifin is a host-directed investigational therapeutic, meaning that it acts on a human protein that the SARS-CoV-2 virus hijacks to synthesize new viruses. As such, zotatifin may have a higher barrier to viral mutational escape than therapies that target components of the virus itself.

For More Such Health News, visit rttnews.com

read more
Australia Cuts Key Interest Rate For Second Time This Year

Australia Cuts Key Interest Rate For Second Time This Year

Australia's central bank lowered its benchmark rate by a quarter-point for the second time this year as risks to inflation became more balanced, while uncertainties regarding economic outlook increased due to trade protectionism measures. The policy board of the Reserve Bank of Australia, governed by Michele Bullock, decided to cut the cash rate target to 3.85 percent from 4.10 percent.
RTTNews | 19 minuter sedan
China Cuts Loan Prime Rates For First Time In 7 Months

China Cuts Loan Prime Rates For First Time In 7 Months

The People's Bank of China reduced its benchmark interest rate for the first time in seven months to stimulate consumption and support the property market amid soothing trade tensions. The central bank lowered its one-year loan prime rate by 10 basis points to 3.0 percent from 3.10 percent.
RTTNews | 1h 46minuter sedan
European Shares Likely To Open On Firm Note

European Shares Likely To Open On Firm Note

European stocks may open on a positive note Tuesday as trade tensions continue to ease, and China's central bank cut interest rates to record lows to stimulate the world's second-largest economy challenged by weak consumer demand and a property crisis.
RTTNews | 2h 47minuter sedan
R&M Refresher Instant Milk Tea Powder Recalled

R&M Refresher Instant Milk Tea Powder Recalled

Lakewood, Washington-based R&M Trading LLC is recalling R&M Refresher brand Instant Milk Tea powder products of various flavors as they may contain undeclared milk, a known allergen, the U.S. Food and Drug Administration said. The Instant Milk Tea products are recalled because the ingredients statement declares Whey and Caseinate in Non-Dairy Creamer ingredients, but it does not specify milk.
RTTNews | 2h 56minuter sedan